Corydalis ternata Nakai alleviates cognitive decline in Alzheimer's disease by reducing β-amyloid and neuroinflammation.

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Recently, natural herbs have gained increasing attention owing to their comparatively low toxicity levels and the abundance of historical medical documentation regarding their use. Nevertheless, owing to a lack of knowledge regarding these herbs and their compounds, attempts to find those that could be beneficial for treating diseases have often been ad hoc; thus, there is now a growing demand for an in silico method to identify beneficial herbs. In this study, the authors present a computational approach for identifying natural herbs specifically effective in treating cognitive decline in Alzheimer's disease sufferers, which analyzes the similarities between herbal compounds and known drugs targeting Alzheimer's disease-related proteins. ternata can improve cognitive decline in Alzheimer's disease sufferers. ternata can be clinically effective for preventing mild cognitive impairment during the early stages of Alzheimer's disease. These findings highlight the potential utility of authors' in silico method and the potential clinical application of the identified natural herb in treating and preventing Alzheimer's disease.

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